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Conclusion: Mushrooms as Nature's Redox Pharmacy Glutathione and ergothioneine represent two evolutionarily tested solutions to the same fundamental biological problem: protecting sensitive molecular structures DNA, membranes, proteins from oxidative destruction

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Data availability Atomic coordinates and structure factors for the crystal structures of the TRF1 TRFH domain in complex with the compounds discussed herein have been deposited in the Protein Data Bank (www.wwpdb.org) and can be accessed using the PDB accession numbers provided in Supplementary Table 3

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